There have been strong prohibitions on research on psilocybin for the past forty years. Psilocybin is a hallucinogenic alkaloid present in Central American mushroom species and produces some effects similar to LSD. Research on the properties of psilocybin shows that it has components for the treatment of depression. It is becoming popular both in the medical field and ordinarily too. Psychotropic doses or large doses of psilocybin have helped people who live with depressive episodes and anxiety disorders adjust and live an inspiring life. There is so much personal research on this topic and a lot of researchers have written books on various aspect of it.
A search on psilocybin shows that micro-dosing is now a trending term for the topic. What is micro-dosing? Micro-dosing means to take a very small amount of a psychedelic. Anecdotes that speak of the benefits of micro-dosing psilocybin are emerging after its break into medical research, and are increasing in number. These benefits include improvement in spiritual development, problem-solving, cognitive enhancement and in the treatment of cluster and migraine headaches.
Micro-dosing as an effective way to treat depression is becoming a fast rising theory that has been tested by some people. Ranging from the videos and articles that are growing on social media that tells of what the treatment can do for you, how to do it to the growing number of people that claimed it worked for them. Further investigation is needed on matters such as these. Therefore a personal research was carried out and finding revealed some information on the topic that people should be aware of before joining the thought train on micro-dosing psilocybin as a treatment for depression. This article is therefore intended to be a guideline and an eye opener as regards the psychopharmacologic mental process behind the usage of psilocybin. This is to the end that whoever chooses micro-dosing psilocybin as a treatment method for depression do so knowing what to expect.
Neurological Mechanisms and Dispelling the Cumulative Theory
There has been awesome news on the science around the use of psilocybin for the last few years. As an example, administering a large dose of psilocybin can increase spiritual fascinating experiences and produce long-term change in an adult’s personality. There is evidence also that psilocybin’s neurophysiologic effect can repeal the nervous functions known to be caused by depressive episodes and anxiety. During the follow-up of the study of micro-dosing psilocybin in the psychedelic subculture, there is a disposition for people to list off the effect of microdose in these studies. It is totally wrong.
The effects of psilocybin depend on the quantity administered therefore taking a larger dose does not imply that the effects will be small just like it has been observed with those who take smaller those. Likewise, there is no evidence to prove the fact that micro-dosing will catalyze in the brain and eventually equal out to give the same effect a larger dose gives. Evidence rather states the contrary.
Psilocin is the only psychotropic metabolite of psilocybin. For psilocybin to completely dissolve into psilocin, it takes about forty minutes. Psilocin has only a life of three hours. It is, therefore, evident that ingesting a microdose of psilocybin probably would not have the effects expected of it on the brain.
Ibogaine, the рsусhоасtіvе аlkаlоіd оf thе hіghlу рsусhеdеlіс Аfrісаn Іbоgа rооt; іs a substance that is aggregated to a larger dose effect through a long-term micro-dosing when present in the brain. It transforms into noribogaine and remains in the blood stream in high concentrations even after twenty-four hours. The overall effect of ibogaine is likely found in the storage of noribogaine as noribogaine produces the same effects as ibogaine. Noribogaine is also believed to be stored in the body’s fatty tissue where it is released in little quantity during the weeks or months following its ingestion.
A pharmacologic overall effect can likely be overruled given that thе оnlу knоwn рsусhоасtіvе mеtаbоlіtе оf рsіlосуbіn іs quickly раssеd оut оf thе bоdу. Therefore, it is advisable that advertisement on how the effects of larger doses of psilocybin can be related to the effect of microdoses should stop. Rather we should start studying and locating the potentials of microdoses.
Spiritual Mechanisms of Psilocybin
Discussing only the reaction between the nerves and drugs does not bother on depression. The ability of psilocybin to produce a metamorphosis when larger doses are induced gives it the ability to counteract the normal operation of a person’s personality. When this happens, it exposes the patient to emotions and feelings that are hidden to his/her mental awareness.
Psilocybin breaks down the defenses that a patient has built to protect himself from memories and emotional trauma which has been buried deep down. The only option the patient has is to give up to a burst of emotions that reveals the honest thoughts within. It brings suppressed emotions to the top of our awareness, giving us the ability and strength to feel them and be mentally lost in them. This means that pieces of memories that are emotionally too difficult to come to terms with which is bound somewhere deep within us can be healed with acceptance and consolidation.
When larger doses are ingested, it is our consciousness of a deep personal weakness coupled with the feelings associated with experiences that are spiritual which cannot be explained; that helps us to heal our emotional injuries on a long run.
Still, the personal weakness does not surface fully when just a little dose is taken. These defenses remain where they are such that acceptance and consolidation does not heal the emotional wound
This does not mean that there is no likely cure for weakness and consolidation with micro-dosing, but that it is probably not likely to arrive at the same depth and readiness as it would be with flood doses. Therefore, demands higher involvement with an incipient weakness to receive perspective, but it is not likely to allow the type of emotional psychosynthesis that larger dоsеs оffеr.
Рsіlосуbіn’s Νеurоlоgісаl Similarity with SSRIs
The number of anecdotal evidence of using micro doses of psilocybin to cure depressive symptoms is increasing on the internet. This is probably because it can help with ameliorating the symptoms. But there is a clear difference between treating, curing and reducing symptoms. One means that the symptoms are under control and the other implies that the symptoms are gone forever. At present Selective Serotonin Reuptake Inhibitors (SSRIs) are a primary pharmacologic treatment for depression in the Western design. The main criticism of SSRIs apart from being over-prescribed is that they only reduce the symptoms by building pharmacologic defenses that further restrain emotions. However micro doses of psilocybin may have similar pharmacologic effects as SSRIs.
In order to fully understand this, it is important to first dissipate the superseded idea that SSRI’s are not effective because of correcting the absence of serotonin or other neurotransmitters. They are effective because they and other types of antidepressants act to lessen and even revoke the neurological changes acquired from long-term stress or depression. They are actually effective in increasing the funсtіоnаl соnnесtіvіtу аnd еvеn nеurоgеnеsіs іn thе hippocampus. These two reactions are also associated with psilocybin’s neurologic effects.
Furthermore, more than other classical psychedelics, psilocybin has a high attractive force with the serotonin HT2b receptor site. Regulation of this particular site is associated with how effective SSRI is a form of medication. While damage to, or genetic lack of this receptor site is associated with SSRI-resistant depression.
Micro-dosing Psilocybin helps to reduce depression with the same chemical reactions as SSRIs, which does not see to the emotional roots of depression. Therefore, if one chooses to microdose psilocybin without making any other changes in his lifestyle and finally stops, the observable effects may wear off and the depression will probably return. What is worse is that depression may even increase because another perceived hopeful treatment has gone out of control. There are people who have suffered this situation. Furthermore, from the above illustration, a person who is resistant to SSRI treatment who micro doses psilocybin may not obtain any result at all. However, in comparison with SSRIs, psilocybin increases resilience and openness rather than creating a balmy omission of complete emotional indifference reported by those who take SSRIs. This qualitative difference may have to do with the study that psilocybin reduces activity in the amygdala, the area of the brain in control of fear or threat response which is overactive in depressed people. Although, long-term antidepressant use does not have this type of effect on those who use it.
Understanding that both micro-dosing of psilocybin and SSRIs can reduce these symptoms means we may be able to move onto micro-dosing with psilocybin in combination with psychotherapy to effectively replace SSRIs. Amazing!
Microdosing Psilocybin Does NOT ‘Heal’ Depression
There are still a lot of possibilities that are waiting to be discovered in this course of study and it is believed that psilocybin can assist a person in their journey of self-discovery.
At larger doses, it could bring one into the roots of his or her trauma and beyond it to the essence of life that illuminates us, giving us the ability to gather who we are from a place of emotional honesty and recovery. At micro doses, it can be a weapon in the arsenal of our healing journey by reducing depressive symptoms, and maybe soften our defenses just enough to give us access to a deeper understanding of who we are, and who we want to be.
People should stop getting their hopes up based on other people’s unproved theories. Micro-dosing psilocybin will not, in anyway cure depression, and the false hope that it will prove to cause more harm than good.
Neither micro doses nor flood doses alone will help a person accept and consolidate the root of their depression. There is no magic cure for depression, whether the dose level is high or not. Forget whаt thе subсulturе аrоund рsіlосуbіn mау tеll us,It is a highly complex condition.
Regardless, a lot of supportive and helpful ways are available to manage depression such as, buffering too much stress while the brain is healing and accepting and feeling the emotions attached to one’s depression. Maybe micro-dosing can be the means for some individuals but be careful to avoid losing hope if it doesn’t work.